Synthetic Biology

In biomedical research, preserving sample authenticity, observing deep structures, tracking molecular dynamics, and achieving quantitative accuracy remain fundamental requirements. Conventional imaging methods are often constrained by fluorescent-label interference, slow acquisition speeds, and limited penetration depth, which in turn restrict breakthroughs in disease-mechanism studies, drug development, and clinical diagnostics. Coherent Raman imaging addresses these challenges through label-free contrast, avoiding phototoxicity and signal interference from fluorescent labeling while preserving the physiological activity of samples such as organoids and living tissues. With submicron spatial resolution and millimeter-scale penetration depth, it can clearly reveal fine structures including tumor infiltration boundaries and neuronal layering, while also distinguishing the distributions of proteins, lipids, and nucleic acids in deeper tissue regions. By recognizing molecular vibrational signatures with high specificity, the technology supports real-time tracking of dynamic processes such as glucose metabolism and lipid synthesis, enabling precise quantification of endogenous molecules. From stem-cell differentiation studies in organoid development and label-free detection of amyloid plaques in Alzheimer's disease to drug-penetration assessment in 3D models and analysis of tumor heterogeneity, this approach provides a new research paradigm for disease-model construction, drug-screening optimization, and precision clinical pathology, helping biomedical research move from static analysis to dynamic tracking and from broad screening to precise quantification.