应用场景

参考资料

1. 1. Ji-Xin Cheng*, X.Sunney Xie*, Vibrational spectroscopic imaging of living systems: an emerging platform for biology and medicine, Science, 2015 (https://www.science.org/doi/10.1126/science.aaa8870)
   2. Shuhua Yue,Junjie  Li, Seung-Young Lee, HyeonJeong  Lee, Tian Shao, Bing Song, Liang Cheng, Timothy A. Masterson,Xiaoqi Liu, Timothy L. Ratliff, Ji-Xin Cheng*, Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metabolism, 2014 (https://doi.org/10.1016/j.cmet.2014.01.019)
   3.Xiaowei Ge, Fátima C. Pereira, Matthias Mitteregger , David Berry, Meng Zhang, Bela Hausmann, Jing Zhang, ArnoSchintlmeister, Michael Wagner, Ji-Xin Cheng, SRS-FISH: A high-throughput platform linking microbiome metabolism to identity at the single-cell level. The Proceedings of the National Academy of Sciences, 2022. (https://doi.org/10.1073/pnas.2203519119)
   4.Haonan  Li, HyeonJeong  Lee, Nathan Tague, Jean-BaptisteJugagne , ChengZong ,Fengyuan  Deng,Jonghyeon  Shin, Lei Tian, Wilson Wong, Mary J. Dunlop, Ji-Xin Cheng, Microsecond fingerprint stimulated Raman spectroscopic imaging by ultrafast tuning and spatial-spectral learning,Nature Communications, 2021 (https://doi.org/10.1038/s41467-021-23202-z)
   5.Chien -Sheng Liao, Mikhail N.Slipchenko , Ping Wang,Junjie  Li, Seung-Young Lee, Robert A.Oglesbee, Ji-Xin Cheng*, Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy, Light: Science & Applications, 2015 (https://doi.org/10.1038/lsa.2015.38)

在5mW Pump，200mW Stokes光下，可探测DMSO 溶液体积比 0.25%

采用高速二维振镜，最高10fps刷新率

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相干拉曼散射成像通过探测目标分子的特征分子键

振动来提供成像所需的对比度，分子特异性高

搭配高倍数物镜，最高可实现300nm成像分辨率

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